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Recently, the effects of SIRT1 on the biological functions of trophoblasts and endothelial cells have gradually emerged, and the expression of SIRT1 is lower in serum samples and placental tissues of pre-eclampsia patients

172 In one study that included 92 women and 46 men undergoing assisted reproductive treatment and 161 controls, MTHFR mutations were correlated with poor in vitro fertilization outcomes and embryonic chromosomal abnormalities

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Additionally, peripheral blood mesenchymal stem cells transplantation activated the IL-10/STAT3 signaling pathway in macrophages within the acne lesions, thereby facilitating the polarization of M2-type macrophages and ultimately reducing the excessive inflammatory response associated with acne, thus achieving the therapeutic objectives of acne treatment