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In other words, MODA's principal mechanism is cytoprotection against cell death, with only indirect or partial influence on restoring the core cholestatic defect of bile flow dynamics, which implies that it may need to be paired with a dedicated choleretic agent for full clinical resolution

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10.1096/fj.08-128348 85 WangZ.MaW.ChabotJ

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Incorporation of genetic variants identified through genome wide association and CVD cohort studies has successfully refined CVD risk prediction models indicating that heritable genetic variants play an integral role in CVD pathogenesis and progression