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Pathak treated an atherosclerotic mouse model with iodomethylcholine (IMC), a mechanism-based inhibitor of choline TMA lyase, and the loss of neutral sterols in mice feces was identified in the form of coprostanol (a bacterial metabolite of cholesterol) (83)

The inflammasome NLRs in immunity, inflammation, and associated diseases

doi: 10.7861/clinmedicine.16-6-s104

These different signaling pathways, which are associated with ER activation and ER inhibition, respectively, depend on cell context with the balance of receptor activation determining the overall response of the cell 78

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