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Foodderived bioactive peptides (e.g., hydrophobic residues like tyrosine, proline, leucine) and synthetic agents (Selank, PT141, GHKCu) can modulate the HPA axis, gutbrain communication, and neuroinflammation, thereby reducing anxiety and improving sleep quality

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The two approaches are complementary, and research suggests that combining injection therapy with exercise-based rehabilitation may produce better long-term functional outcomes than either alone