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Rosenthal DI , Nurenberg P, Becerra CR, Frenkel EP, Carbone DP, Lum BL, Miller R, Engel J, Young S, Miles D, Renschler MF

doi: 10.1080/08916930701619235 93

By managing the silence of transposable elements and regulating gene expression, piRNAs play a critical role in protecting the germline in mammalian oocytes and early embryonic stages, maintaining genomic integrity and guaranteeing appropriate developmental progression [551, 552]

No human dosing studies have been published, and no oral dose equivalents have been established due to the absence of oral bioavailability data