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The mechanism may be related to the decreased inflow of iron, TF and TFR1, the upregulation of GPX4, xCT, and FTH1, and the downregulation of ACSL4, MDA and LPO levels

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In addition, the activities of key enzymes that are involved in MG metabolism, including GlO1, GlO2, and D-lactate dehydrogenase, were significantly reduced in the kidney injury model, indicating a decreased MG detoxification capacity

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4.3.1 Melatonin inhibiting glycolysis in T-cell malignancy Glycolysis is a metabolic mechanism that transforms glucose into pyruvate and generates ATP, the primary source of energy for cells