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Response: We continue to believe that the procedures described by CPT codes 38225, 38226, and 38227 describe the various steps required to collect and prepare the genetically modified T-cells, and Medicare does not generally pay separately for each step used to manufacture a drug or biological product

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Minor side effects & safety profile While AOD 9604 appears to have a favorable tolerability profile in early trials, there are still relevant caution points: Reported/mild side-effects Injection-site reactions: redness, swelling, itching, mild pain

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Neurons have unique compartmentalized anatomy and energy requirements, and each compartment requires continuously renewed mitochondria to maintain neuronal survival and activity