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A 20% loss of initial body weight was selected as a humane endpoint for mice in the SURV experiment as previously described [17]

Major market regulations European Union: EU regulations generally mirror FDA approaches, with approved pharmaceutical peptides and restrictions on unapproved therapeutic claims

Another aspect of the invention pertains to the use of small molecule quinoline derived cations of Formula IA for muscular therapy, wherein: R 5 is H or NH 2 , R 6 is H or F R 7 is H or NH 2 , R 8 is H or methyl