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found deferoxamine combined with arsenic trioxide has synergistic inhibitory effect than monotherapy on HL-60 cells in a nude mouse model, with no significant side effects

Modulation of the enzyme proved challenging because it has multiple functions in the body

Seahorse XF Mito fuel flex test The dependency, capacity, and flexibility of cells to oxidize three major mitochondrial fuels (glucose, glutamine, and long chain FAs) were determined using a Seahorse XF Mito Fuel Flex Test Kit (103260-100, Agilent Technologies, Santa Clara, CA, USA) on a Seahorse Bioscience XF24-3 Extracellular Flux Analyzer (Agilent Technologies)