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" Maintaining hormone levels is essential for anyone who wants to age gracefully ," Attia emphasizes, noting that testosterone in particular has a critical role in maintaining muscle mass, bone density, and even mental sharpness

Lastly, some studies in mice have found that sirolimus can restore the self-renewal capacity of some hematopoietic stem cells, thereby mitigating stem cell exhaustion.8 Studies are currently underway to investigate the potential of sirolimus as an mTOR inhibitor and an agent for mitigation of age-related disease

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Similar therapeutic effects have been demonstrated in a SOD1 G93A mouse model of ALS [78], but the efficacy diminishes during later stages of the disease [79]