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The cytotoxic K + in endolymph could reach the tympanic scala through the orifice of the cupula cochleae and then reach the lymphatic space of the Cortis organ, where the contact of K + with hair cells leads to the destruction of cochlear sensory epithelial cells, atrophy of stria vascularis and degeneration of auditory nerve fibers

However, LeGSTU2 expression was repressed by low temperature

Oxidation of glutathione by hydrogen peroxide and other oxidizing agents

The measured conclusion is not that KLOW is necessarily dangerous, but that its safety is genuinely unknown, that at least one core component has been formally flagged for safety concerns, and that the blend, the dose, and the sourcing all add further uncharacterized risk

Figure 4 Table 3 Top 10 most relevant countries/regions for oxidative stress research in DCD