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The change of each outcome variable was summarized by cohort, and a linear model with GEE was used to test whether there was a statistically significant change while accounting for correlation between eyes within each cohort

If an adverse effect, or even the inconvenience, of a particular therapy outweighs the benefits for the patient, then it might not be worthwhile to include it in a management strategy

2 Gut microbiota characteristics in children with ASD Studies have shown that there is a close association between ASD and gut microbiota dysbiosis (Su et al., 2024)

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However, in view of their poor hydrophilicity, the introduction of nanoparticles is beneficial to improve their penetration into the mucosa