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Gottrons papules or Gottrons sign (bumps found over the knuckles, elbows, and knees, often with a raised, scaly break-out) Itching and changes in the scalp resembling psoriasis and hair loss Ragged cuticles, prominent blood vessels on the nail folds, and other nail-bed abnormalities Nonerosive inflammatory polyarthritis Joint inflammation Lung problems such as Interstitial Lung Disease (ILD), Pulmonary Fibrosis, or Labored breathing (dyspnea) Difficulty swallowing (dysphagia) Dry, scaly, or rough skin Fatigue (may be life-altering and disturb sleep patterns) Weight loss Low-grade fever Muscle pain (myalgia) Other symptoms and complications Some patients may develop one or two complications, but rarely all of them

The GNCsiRNA protected the siRNA from degradation, facilitated the cellular uptake, and the GNCsiRNA can escape from the lysosomes to the cytoplasm for effective siRNA-mediated gene silencing