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ME/CFS can affect multiple organs and is characterized by at least six months of moderate-to-severe symptoms affecting three core areas: Other common symptoms can include: These varied symptoms are a result of dysregulation across the neuro-immune system, hormonal regulation, and even cardiovascular and gastrointestinal systems

an important, but neglected, relationship in medicine

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Secondly, the objective to offer a broad overview of oxidative stress might have resulted in insufficient depth and detail regarding specific mechanistic insights, limiting a thorough examination of particular facets of the topic