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A phase 2 trial on heavily pretreated rGB patients noted adequate pharmacokinetics but ultimately showed limited efficacy, leading to the trials termination ( Ribociclib, another CDK4/6 inhibitor, also displayed minimal clinical activity in a phase 0/2 surgical trial on rGB patients ( 4 Repurposing targeted drugs in GB: challenges and solutions Below described are the main barriers to GB targeted therapy, which is a field largely dependent on repurposed drugs, with a few exceptions outside the scope of this review

This could provide an explanation for findings from previous studies which confirmed the capacity of A

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S2CID 24097516

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