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By correlating structural data with biochemical activities, we find that Ran-GTP, but not Ran-GDP, constrains the solenoid structure of importin , closing high-affinity FG-binding pockets and displacing import cargos through allosteric crosstalk between the concave and convex surfaces

Am J Biopharm Pharm Sci 2022;2:8

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Adipocyte-specific loss of p53 augmented the metabolic health benefits of IF, thus representing a novel mechanism that could be therapeutically utilised to boost the effectiveness of dietary interventions and to overcome retained AT dysfunction upon weight loss in formerly obese patients