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In humans, a glucose load is associated with postprandial changes in many metabolites, including an increase in blood pyruvate (22) and a decrease in plasma Pi (23) , which are known to have opposing effects on 2,3-DPG metabolism

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Excretion Pathways Limited data exists on specific excretion pathways for topically applied Syn-AKE: Degradation products likely eliminated through normal peptide metabolic pathways Renal clearance probable for any systemically absorbed peptide or fragments No accumulation detected in repeated-use studies (manufacturer data) Excretion kinetics require further investigation through labeled peptide studies The reversible nature of Syn-AKEs effects and absence of reported accumulation issues suggest efficient clearance mechanisms, though detailed elimination studies are lacking in peer-reviewed literature

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