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Some show greater organ stress, while others feel emotionally exhausted by long-term dependence on treatment

suggested that dupilumab-induced IL-4 inhibition leads to Th1/Th17 polarization, resulting in increased expression of IL-17, IL-2, TNF-, and IFN-, which are implicated in the pathogenesis of vitiligo (47)

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Some studies suggest a positive correlation between dose and efficacy, but subsequent studies have found no difference ( 9.5 Patient selection The success of cell therapy largely depends on the precise selection of patients

10.3389/fragi.2023.1148926 71 GarmanyA.YamadaS.TerzicA