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For the general patient population, this has no clinical relevance

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Buffering by proteins accounts for two-thirds of the buffering power of the blood and most of the buffering within cells

A multiple imputation approach was used to handle missing data 31 , with imputation based on available data from participants in the same treatment arm with the same treatment status (on-treatment or discontinued)

This triple mechanism distinguishes it from dual-agonist peptides like tirzepatide (GLP-1/GIP) and single-agonist compounds like semaglutide (GLP-1 only), making it the most broadly acting incretin-class compound currently under clinical investigation