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The effects exerted by these enzymes reduce ROS-mediated cellular damage in epidermal keratinocytes, which is closely associated with abnormal proliferation and decreased apoptosis

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This demonstrated a critical role of activated Akt in EP4-induced cancer cell migration and invasion (Dillon and Muller, 2010)

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3) Downregulation of GPX4 occurs even in presymptomatic stages of disease in mouse models (368, 371)

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By contrast, heterodimerization with AP-1 family proteins, such as c-Jun, redirects their binding toward AP-1 sites (74,78,92-94)

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