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(77) reported a decrease in the gene expression of MMP-2 and MMP-9 alongside an increase in TIMP1 expression in murine skin exposed to UVB radiation when 20 mg/kg areca nut PCs were orally administered to mice, indicating their ability to mitigate collagen degradation and slow photoaging effects on the skin through the inhibition of the MAPK signaling pathway

This PTM-related research will facilitate future clinical applications of phase transition for RBPs

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Galangin suppresses PI3K/Akt signaling in both MCF-7 cells and human nasopharyngeal carcinoma cells, downregulating cyclin D3/B1 and CDK1/2/4 while elevating p21/p53 levels

Although the physiological role of melanin in plants remains poorly understood, it is structurally distinct from animal melanin, as it typically lacks nitrogen and is synthesized via the oxidation of flavonoids through the activity of enzymes such as PPO and peroxidase (POD) (Glagoleva et al