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DNA methylation in folate deficiency: use of CpG methylase

49 A randomized controlled trial that enrolled 66 participants with sudden sensorineural hearing loss compared corticosteroid treatment plus 78 mg oral zinc gluconate (providing 20 mg of elemental zinc) daily to corticosteroids alone

Moro, T., Brightwell, C

Blood Adv 4(13):30003010 Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H (2015) Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

Most individuals tolerate MSM exceptionally well, with side effects being rare and typically limited to mild gastrointestinal issues like bloating or nausea