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Upon activation, choline dehydrogenase (CHDH) accumulates on the outer mitochondrial membrane (OMM), interacts with p62, and recruits autophagy adapters to depolarized mitochondria

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Plasma IGF-1 concentrations are low in severe thyroxine deficiency and rise with thyroid hormone replacement

Another study showed that intragastric delivery of low and high-dose EGCG over 60 days can prevent A buildup and cognitive decline in senescence-accelerated mice P8

5.2 Liver Injury There have been rare postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure in patients treated with ORLISTAT, with some of these cases resulting in liver transplant or death