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In contrast, our study confirmed decreased glutathione levels and increased ROS levels through BSO treatment or GCLC silencing, and revealed that while the depletion of glutathione did not compromise lymphoma cell survival in 2D culture, it sharply diminished viability in 3D gels

In contrast to GBM, neuroblastoma (NB), which originates from the sympathetic nervous system, has a lower malignancy level and primarily affects children [149]

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For example, the inhibition of mTOR enabled TFEB dephosphorylation and translocation the later increased the expression of genes encoding lysosomal proteins, such as V-ATPases, lysosomal transmembrane proteins, and hydrolases 93