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However, therapeutic applications of ROS modulation face challenges, particularly the systemic toxicity of ROS-targeting agents, which mirrors the substantial side effects associated with traditional chemotherapy and radiation therapy

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the com osition comprises the hemiacetal of Formula II: each R l s R 2 , R 3 , R4, and R 5 is independently selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, acyloxy, cycloalkyl, cycloheteroalkyl, alkoxy, alkoxyamino, alkoxycarbonyl, cycloalkoxy, cycloalkenyl, cyano, cyanato, aryl, arylalkyl, alkylaryl, aryloxy, heteroaryl, heteroaryloxy, amino, amino alkyl, alkylarylamino, alkylamino, amino carbonylamino, amino carbonyloxy, arylamino, azido, bicycloaryl, carbamoyl, carboxy, carboxyamino, heteroarylamino, alkylsufonyl, alkyl thio, and sulfone