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doi: 10.3389/fphar.2025.1611911 Received 15 April 2025 Accepted 16 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Huanling Lai, Guangzhou National Laboratory, China Reviewed by Wenrui Xia, Chengdu University of Traditional Chinese Medicine, China Wenjun Wang, Hong Kong University of Science and Technology, Hong Kong SAR, China Updates Copyright 2025 Liu, Mu, Qi, Li and Hu

Antimicrobial sulfonamides contain an arylamine group at the N4 position, which accounts for the drugs antimicrobial function through competitive inhibition of a structurally similar compound needed for microbial processes

Not only does it directly participate in the battle against ferroptosis through the antioxidant mechanism of NO, but it also indirectly promotes the health and regenerative capacity of skin cells by supporting the synthesis of folate