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Categorical variables were conveyed as frequency with percentage while continuous variables were described as mean and standard deviation (SD) or median with interquartile range (IQR)

Thus, the Rasch-based method for developing weighted scales was applied to questions related to activities of daily living in patients with ALS to create the 28-question Rasch-built Overall ALS Disability Scale (ROADS) [35, 36]

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These synthetic forms are not biologically active in the same way as the natural L-isomer and can actually competitively inhibit the absorption and utilization of naturally occurring L-carnitine, potentially inducing a state of carnitine deficiency and worsening fatigue symptoms

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