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Rempe, R

Therefore, our study explored the impact of metformin on the proliferation, differentiation, and ferroptosis of endogenous NSCs during SCI repair through in vitro and in vivo experiments, further highlighting the role and molecular mechanisms of metformin in neuroregeneration and neuroprotection

Initially, these abnormal signals are perceived by intracellular stress sensors, initiating UPR (115)

Upregulation of Nrf2 activity has been shown to promote mitochondrial biogenesis via peroxisome proliferatoractivated receptor gamma coactivator-1 alpha (PGC-1) and to improve the expression of genes involved in mitochondrial quality control, such as mitofusin-2 (MFN2) and optic atrophy 1 (OPA1)

Coffee consumption and oxidative stress: A review of human intervention studies