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Under pathological conditions, mitochondrial damage not only promotes translational activation of ATF4, but also induces transcriptional upregulation of the ROS-p38 MAPK-activating transcription factor 2 (ATF2) signaling axis driven by FGF-21 [102]

Future research should aim to standardize diagnostic frameworks and stratify patients based on molecular or clinical subtypes to improve study reproducibility and relevance

These are implicated in the pathogenesis of AD and used as an indicator of disease severity

An experiment was done to explain the effect of test agents alone in order to assure their safety before looking at how test agents affected the toxicity of DOX