chac1 glutathione degradation of enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases

Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione degrading enzyme CHAC1 ScienceDirect Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link Frontiers Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv

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