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In hepatocellular carcinoma (HCC) studies, ADI-PEG-20 has been shown in early clinical trials to make HCC animal models and patients more sensitive to FOLFOX chemotherapy through arginine depletion

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Peptides identified from phage libraries that have been used for HAdV retargeting to the tumour vasculature include the RGD-binding cellular integrins [22], NGR peptide-binding aminopeptidease N (APN) [23] and human epidermal growth factor (EGFR) GE11 peptide [24]