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It's another possible mechanism for affecting metabolism

Front Cardiovasc Med 10:1005408 Yang CC, Chen KH, Yue Y, Cheng BC, Hsu TW, Chiang JY et al (2024) SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal protection

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In this regard, EPOP is projected to impair PRC2.1 PHF19 or PRC2.1 MTF2 chromatin targeting by displacing the DS helix, unlocking the stabilized dimer, and thereby promoting the structural transition from the dimeric state into the monomeric state (Fig