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8,9 Furthermore, smokers inhale 1 g of iron per 25 cigarettes and the smoke itself releases iron from ferritin, giving the lung surface fluid ample iron to generate the toxic hydroxyl radical through the Haber-Weiss and Fenton reactions

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In line with animal research, clinical data using tailored proton magnetic resonance spectroscopy demonstrated that people with cocaine use disorder have reduced basal glutamate concentrations and increased glutamate levels in the nucleus accumbens during cue-induced craving [15]