glutathione low elevated ferritin Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from by the physiologically-occurring Cu(I)–glutathione complex Hyperferritinemia • The Blood Project
Hyperferritinemia The Blood Project Hyperferritinemia and inflammation PMC Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. Frontiers Ferroptosis and bone health: bridging the gap between mechanisms and therapy Sustained dysregulation of iron and glutathione homeostasis induces chronoferroptosis, a persistent ferroptotic adaptation in neuronal cells Cell Death Discovery
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