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H 2 S has been shown to reduce the production of ROS and pro-inflammatory cytokines such as TNF- and IL-1 in microglia, demonstrating its potential to mitigate neuroinflammation and provide neuroprotection ( Targeting ATP Signaling: Drugs that modulate eATP concentrations in the CNS are emerging as potential therapies for neuroinflammation, given eATPs roles in synaptic transmission, mood disorders, cortical spreading depression, and microbiota-gut-brain axis signaling ( Modulating Cytochrome C: Cytochrome C release from mitochondria can trigger apoptosis and inflammation

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Researchers now understand that up to 50% of patients with these intersecting post-viral syndromes suffer from an underlying condition called Small Fiber Neuropathy (SFN)

10.1016/S0005-2736(99)00085-1