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Gene set enrichment assay (GSEA) GSEA was conducted using the GSEA program provided by the Broad Institute ( All samples from the GSE39582 and GSE87211 datasets were first grouped according to KRAS mutation isotypes and then further subdivided based on HER2 or ELF3 expression levels (top 33%/bottom 33%) to define the phenotypes within the datasets

Hepatocyte triglyceride accumulation and cholesterol dysregulation also directly drive HSC activation via induction of the Hippo pathway (146, 199)

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Based on our findings, we introduced YK1, a small molecule inhibitor that disrupts the ELF3-MED23 interaction, leading to the transcriptional downregulation of HER2 and KRAS

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