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386 Cationic lipids incorporating a guanidinium functional group represent another option for RNA delivery because guanidinium has the following characteristics: (a) The guanidine is a basic functional group with a p K a value at about 13.5, so it can be protonated over a wide range of pH environments, resulting in a permanently positively charged guanidinium head group at physical pH

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The function of luteal tissue becomes compromised when ambient temperatures rise because they enhance reactive oxygen species (ROS) production in luteal cells