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Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder

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They are also involved in the inception and pathogenesis of several chronic diseases including neurodegenerative disorders, diabetes, aging processes, arthritis, cardiovascular impairment, chronic inflammation, and hepatic disorders 33