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Because vascular relaxation is a critical process to maintain blood pressure (143), evidence indicates that arsenic exposure can contribute to hypertension (one of the key characteristics of the MS) by disrupting NO signaling and K + currents in the endothelium and vascular smooth muscle cells

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, 35 , 238-245, Oishi, T., Matsumaru, D., Ota, N., Kitamura, H., Zhang, T., Honkura, Y., et al

The changes in gene transcription led to changes in the synthesis of proteins that affect various physiological processes, including metabolism, development, and growth