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UCN3 takes a main part in mediating few important biological processes, specially those associated with energy metabolism, stress response and the regulation of the hypothalamic-pituitary-adrenal (HPA) axis

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In conclusion, by targeting senescence, we offer a strategy that simultaneously decreases radioresistance of [nonsmall cell lung cancer] and the incidence of RIPF. Not only were the fibroblasts (cells commonly found in connective tissue) more susceptible to radiation therapy treatment instead of being more resistant to it, but it also treated damage and scarring to lung tissue induced by radiation therapy

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[PubMed] [Google Scholar] 39.Gilham D, Alam M, Gao W, Vance DE, Lehner R