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10.1371/journal.ppat.1004144 265 Puzio-KuterA

Erdman JW, MacDonald IA, Zeisel SH

Respirology 23 , 1213 (2018)

Evidence has shown their capability to increase the expression of NRF2 target genes in cellular and in vivo models of chronic obstructive pulmonary disease (COPD) [298], and to interfere with the direct PPI between KEAP1 and NRF2 or the PPI between KEAP1 and CUL3 [299, 300]