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In a clinical trial of people with Type 2 Diabetes, a group known to be deficient in glutathione, liposomal glutathione was given for three months

These molecules prevent cumulative cellular damage associated with chronic oxidative stress, which contributes to inflammatory, neurodegenerative processes, premature aging and a range of chronic diseases [31], non-communicable diseases such as cardiovascular, neurodegenerative, certain types of cancer and conditions related to premature ageing [14, 32]

For example, a randomized controlled trial indicated that patients receiving SERMs experienced a marked improvement in pigmentation scores after 12 weeks of treatment

Many of the studies evaluating different combinations of antioxidants, however, have used different methodologies, impeding replication.71 There is insufficient clinical evidence to recommend the use of dietary supplements in the management of skin aging, and some authors urge caution when it comes to recommending vitamins or dietary supplements to well-nourished individuals.72 Promising results have been observed with extracts from plants such as Aloe vera, Citrus paradisi, Rosmarinus officinalis, Cyclopia intermedia, and Hydrangea serrata,73 but clinical evidence is lacking

Glutathione Metabolism Glutathione is the principal reducing agent in erythrocytes and the essential cofactor in the glutathione peroxidase reaction