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4.1 Reduced oxidative and biosynthetic metabolism through the Krebs cycle Figure 4 prominently illustrates a decrease of Krebs cycle intermediates (citric, cis-aconitic, isocitric, 2-ketoglutaric, and succinic acids) and associated organic acids (trans-citric, 2-hydroxyglutaric, and methylcitric acids) as giraffe milk transitions from mid to late lactation

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Further, the upregulation of REST in AKI suppressed GCLM transcription and reduced GCL enzymatic activity, leading to the downregulation of GSH and GPX4