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The study revealed that, in the presence of mutant HTT, a significant portion of genes with altered expression exhibited pronounced changes in DNA methylation, particularly in regions with low CpG content known to undergo methylation changes due to neuronal activity

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This technique significantly enhances yield and efficiency compared to conventional methods, allowing for higher concentrations of bioactive compounds in a much shorter extraction time ( However, the ultrasound-assisted extraction also has its limitations ( 3.1.2 Microwave-assisted extraction method Microwave-assisted extraction is an environmentally friendly technique used to isolate polyphenols from plants, herbs, and plant-based products ( Microwave-assisted extraction is frequently employed to recover polyphenols from agricultural by-products and processed wastes, such as pomace, leaves, and peels ( This technique significantly reduces extraction time and energy consumption compared to conventional methods

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