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Such a staged program would help determine not only whether a compound is protective, but also whether it acts by stabilizing an upstream contact-site defect, limiting secondary amplification, or merely delaying terminal bioenergetic failure

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These typically resolve within hours to days and diminish with repeated doses

For example, a large expansion of the astacin protease and CAP gene families coincided with the emergence of parasitism in the animal parasitic Strongyloides nematodes [10] whilst gene duplication is proposed to have been an important driver of parasitism in the Orobanchaceae plant parasites [11]