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The knife starts the clock: into the fridge within 2 hours, eaten within 3 to 5 days, frozen for smoothies if you can't keep up

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Taken together, these data show that initiation of dietary MR induces an mTOR- and Erk1/2-dependent stress response that is linked to ATF4 by the sharp, initial drop in hepatic methionine and resulting repression of translation pre-initiation