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The same study also demonstrated that perturbing glutamine pathway either via glutamine depletion or by using specific chemical inhibitors or due to genetic polymorphism (e.g., GLS2, SLC7A5, and SLC1A5), decreased T-cell associated cytokine production by the macrophages (PMID: 30541099)

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Taken together, hypoxic stress creates a favorable environment for myeloma survival by regulating chemotaxis, stimulating osteoclasts and endothelial cells, and inhibiting osteoblasts ( Figure 1 )

[2] It is a rich food source of vitamin K 2 variant MK-7, made by the bacteria