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S.AbrassartD.KobayashiY.MarchevaB.et al (2009)

Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer

Watzl, B., Leitzmann, C

Its enhanced stability and high receptor affinity produce consistent activation of downstream pathwaysmTOR, MAPK, and PI3K/Aktcritical for studies of cell proliferation , protein synthesis , and glucose metabolism