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Eur J Immunol 34 : 26902698 Korzenik JR and Dieckgraefe BK (2000) Is Crohn's disease an immunodeficiency

The problem with choline, and the reason to avoid supplementing it, is that it has been found (along with L-carnitine) to increase the amount of trimethylamine N-oxide (TMAO) in the dogs' blood