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These enzymes catalyze the formation of key regulators of calcium signaling, namely (linear) ADP-ribose, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate ( Figure 5 )

In particular, Akt phosphorylation, compared to ERK phosphorylation, appeared to be more sensitive to the phosphorylation of Met, which is evident by the dramatic reduction in pAkt in the case without 51 (Fig